[ Usage oral/Gobber ]
Possibilité de gober du cannabis au lieu de fumer

Dernière modification par prescripteur (09 mai 2024 à  10:33)

Dernière modification par Popiesse (09 mai 2024 à  11:47)

Bonsoir Xanax.
Peut tu nous en dire un peut plus? Je ne savais pas cela et j’aimerais bien savoir que fait cette enzyme etc . Je suis étonné que l’on puisse manger un bon bout de shit et ne rien ressentir.
Donc si tu en sais plus et à le temps hésites pas à poster qqs infos complémentaires stp .

Salut ! Je passe en coup de vent. Je n'ai pas le temps de traduire cette fois, mais je trouve ça important de te répondre. Je pensais que tout le monde le savait, désolée, c'est pour ça que je n'ai pas plus expliqué


Comment le THC est métabolisé en ingestion

Sirichai Chayasirisobhon, [label=/sujet/mdma a écrit

MD[/label], FAAN]In 2005 researchers found that a certain CYP2C9 variant metabolized 30 percent less THC than another in the same amount of time. The study was conducted using enzymes in a lab.

But there’s also been at least one clinical study conducted with human participants. It was published in the journal Clinical Pharmacology & Therapeutics in 2009 and found that CYP2C9 efficiency is higher for carriers of a certain genetic variant. The study measured THC and metabolites 11-OH-THC and THC-COOH over time in 43 volunteers who were given 15 milligrams of oral THC. For those whose variant produced a more efficient enzyme, the effects and presence of THC deteriorated much more quickly.

The study had a very small sample size, indicating that there could be many other variants out there with differing levels of CYP2C9 efficiency. All signs point to the likelihood that there is at least one rare CPY2C9 genetic subtype out there that produces an enzyme that processes THC so fast that it doesn’t have time to produce any psychoactive effects

Pourquoi certains ne ressentent pas d'effets, ou très peu lors de l'ingestion

Josh Lee - The paper a écrit

When a consumer eats an edible, however, the THCA has already been converted into Delta-9 THC during the preparation process. The compound then travels through the gastrointestinal tract and the liver, where the Delta-9 THC is broken down into a metabolic byproduct called 11-hydroxy THC.

This form of THC is much more potent than Delta-9 THC and produces a different experience than smoking altogether. Because it has to be digested, it can take up to 90 minute or longer for an edible to start working, and the effects can last for hours instead of minutes.

Users report that edible cannabis also produces more psychedelic effects than the smoked variety. Red Rock Roasters  An enzyme called cytochrome P2C9 (CYP2C9) in the liver and GI tract is responsible for breaking down Delta-9 THC. This enzyme is used as part of the first steps of your body’s metabolizing process. It also breaks down other drugs and hormones. The amount of time it takes to break down THC metabolites is totally dependent on the performance of CYP2C9, and it appears that an individual’s CYP2C9 performance is based on which version of a specific gene they carry.

For some unlucky individuals of a certain genetic subtype, their GI tract produces an enzyme that breaks down THC faster than in others, totally preventing them from feeling the effects of edibles. In 2005 researchers found that a certain CYP2C9 variant metabolized 30 percent less THC than another in the same amount of time. The study was conducted using enzymes in a lab.

But there’s also been at least one clinical study conducted with human participants. It was published in the journal Clinical Pharmacology & Therapeutics in 2009 and found that CYP2C9 efficiency is higher for carriers of a certain genetic variant. The study measured THC and metabolites 11-OH-THC and THC-COOH over time in 43 volunteers who were given 15 milligrams of oral THC. For those whose variant produced a more efficient enzyme, the effects and presence of THC deteriorated much more quickly.

The study had a very small sample size, indicating that there could be many other variants out there with differing levels of CYP2C9 efficiency. All signs point to the likelihood that there is at least one rare CPY2C9 genetic subtype out there that produces an enzyme that processes THC so fast that it doesn’t have time to produce any psychoactive effects

Kalei a écrit

Oh .
Ok . Très intéressant .
Merci pour la réponse

Avec grand plaisir !